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Year Number of Results
1947 1
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1949 2
1951 1
1953 1
1954 1
1955 2
1959 1
1961 1
1962 5
1963 3
1964 14
1965 23
1966 17
1967 23
1968 41
1969 32
1970 41
1971 62
1972 70
1973 77
1974 86
1975 149
1976 173
1977 164
1978 155
1979 160
1980 215
1981 186
1982 234
1983 339
1984 355
1985 410
1986 411
1987 443
1988 533
1989 579
1990 721
1991 789
1992 845
1993 962
1994 1156
1995 1315
1996 1441
1997 1365
1998 1447
1999 1527
2000 1612
2001 1662
2002 1518
2003 1572
2004 1653
2005 1685
2006 1736
2007 1718
2008 1752
2009 1634
2010 1664
2011 1645
2012 1661
2013 1558
2014 1431
2015 1461
2016 1348
2017 1198
2018 1159
2019 1159
2020 1160
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2024 324

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Growth Kinetics of Influenza C Virus Antigenic Mutants That Escaped from Anti-Hemagglutinin Esterase Monoclonal Antibodies and Viral Antigenic Changes Found in Field Isolates.
Matsuzaki Y, Sugawara K, Shimotai Y, Kadowaki Y, Hongo S, Mizuta K, Nishimura H. Matsuzaki Y, et al. Viruses. 2021 Mar 3;13(3):401. doi: 10.3390/v13030401. Viruses. 2021. PMID: 33802440 Free PMC article.
Using selection with anti-HE monoclonal antibodies, we previously obtained some escape mutants and identified four antigenic sites, namely, A-1, A-2, A-3, and Y-1. To confirm whether the residues identified as the neutralizing epitope possibly relate to the antig
Using selection with anti-HE monoclonal antibodies, we previously obtained some escape mutants and identified four antigenic s …
Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies.
Gerhard W, Yewdell J, Frankel ME, Webster R. Gerhard W, et al. Nature. 1981 Apr 23;290(5808):713-7. doi: 10.1038/290713a0. Nature. 1981. PMID: 6163993
Thus, in characterizing the antigenic structure of the HA molecule, our approach has been (1) to generate a panel of monoclonal anti-HA hybridoma antibodies, (2) to use some of these antibodies to select mutants of the influenza A/PR/8/34 (PR8) virus expressing a
Thus, in characterizing the antigenic structure of the HA molecule, our approach has been (1) to generate a panel of monoclonal anti- …
Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model.
Guarnaccia T, Carolan LA, Maurer-Stroh S, Lee RT, Job E, Reading PC, Petrie S, McCaw JM, McVernon J, Hurt AC, Kelso A, Mosse J, Barr IG, Laurie KL. Guarnaccia T, et al. PLoS Pathog. 2013;9(5):e1003354. doi: 10.1371/journal.ppat.1003354. Epub 2013 May 9. PLoS Pathog. 2013. PMID: 23671418 Free PMC article.
Surveillance data indicate that most circulating A(H1N1)pdm09 influenza viruses have remained antigenically similar since they emerged in humans in 2009. However, antigenic drift is likely to occur in the future in response to increasing population immunity induced …
Surveillance data indicate that most circulating A(H1N1)pdm09 influenza viruses have remained antigenically similar since they emerge …
Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin.
Knossow M, Daniels RS, Douglas AR, Skehel JJ, Wiley DC. Knossow M, et al. Nature. 1984 Oct 18-24;311(5987):678-80. doi: 10.1038/311678a0. Nature. 1984. PMID: 6207440
We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional structure of the HA from an antigenic mutant containing a single amino acid substitution which was selected by growth of virus in th …
We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimensional struct …
Predicting the Mutating Distribution at Antigenic Sites of the Influenza Virus.
Xu H, Yang Y, Wang S, Zhu R, Qiu T, Qiu J, Zhang Q, Jin L, He Y, Tang K, Cao Z. Xu H, et al. Sci Rep. 2016 Feb 3;6:20239. doi: 10.1038/srep20239. Sci Rep. 2016. PMID: 26837263 Free PMC article.
Mutations of the influenza virus lead to antigenic changes that cause recurrent epidemics and vaccine resistance. ...With templates of antigenic sequences, the model can effectively predict the potential distribution of future antigenic mutants. ...
Mutations of the influenza virus lead to antigenic changes that cause recurrent epidemics and vaccine resistance. ...With templates o …
Immunological transitions in response to antigenic mutation during viral infection.
Wahl LM, Bittner B, Nowak MA. Wahl LM, et al. Int Immunol. 2000 Oct;12(10):1371-80. doi: 10.1093/intimm/12.10.1371. Int Immunol. 2000. PMID: 11007754 Review.
Antigenic variation is an important factor in viral persistence and disease progression. We analyze immunological changes which occur in response to antigenic mutation during chronic viral infection. Using an established model of viral and immune system dynamics, we
Antigenic variation is an important factor in viral persistence and disease progression. We analyze immunological changes which occur
The Molecular Determinants of Antibody Recognition and Antigenic Drift in the H3 Hemagglutinin of Swine Influenza A Virus.
Abente EJ, Santos J, Lewis NS, Gauger PC, Stratton J, Skepner E, Anderson TK, Rajao DS, Perez DR, Vincent AL. Abente EJ, et al. J Virol. 2016 Aug 26;90(18):8266-80. doi: 10.1128/JVI.01002-16. Print 2016 Sep 15. J Virol. 2016. PMID: 27384658 Free PMC article.
We tested the antigenic effect of these introduced substitutions by using hemagglutination inhibition (HI) data with monovalent swine antisera and antigenic cartography to evaluate the antigenic phenotype of the mutant viruses. Combinations of substitu …
We tested the antigenic effect of these introduced substitutions by using hemagglutination inhibition (HI) data with monovalent swine …
Meningococcal outer membrane vesicle vaccines derived from mutant strains engineered to express factor H binding proteins from antigenic variant groups 1 and 2.
Koeberling O, Giuntini S, Seubert A, Granoff DM. Koeberling O, et al. Clin Vaccine Immunol. 2009 Feb;16(2):156-62. doi: 10.1128/CVI.00403-08. Epub 2008 Dec 24. Clin Vaccine Immunol. 2009. PMID: 19109451 Free PMC article.
However, the vaccines elicit serum bactericidal antibody responses largely directed against PorA, which is antigenically variable. We previously prepared a native (non-detergent-treated) OMV vaccine from a mutant of group B strain H44/76 in which the lpxL1 gene was …
However, the vaccines elicit serum bactericidal antibody responses largely directed against PorA, which is antigenically variable. We …
Immunogenicity of Wild Type and Mutant Hepatitis B Surface Antigen Virus-like Particles (VLPs) in Mice with Pre-Existing Immunity against the Wild Type Vector.
Kingston NJ, Walsh R, Hammond R, Joe CCD, Lovrecz G, Locarnini S, Netter HJ. Kingston NJ, et al. Viruses. 2023 Jan 23;15(2):313. doi: 10.3390/v15020313. Viruses. 2023. PMID: 36851527 Free PMC article.
Virus-like particles (VLPs), composed of the small hepatitis B virus surface antigen (HBsAgS), are the antigenic components of the hepatitis B virus (HBV) vaccine and represent the backbones for a chimeric anti-malaria vaccine and various vaccine candidates. ...In o …
Virus-like particles (VLPs), composed of the small hepatitis B virus surface antigen (HBsAgS), are the antigenic components of …
Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses.
Xu C, Zhang N, Yang Y, Liang W, Zhang Y, Wang J, Suzuki Y, Wu Y, Chen Y, Yang H, Qiao C, Chen H. Xu C, et al. J Virol. 2022 Aug 24;96(16):e0097122. doi: 10.1128/jvi.00971-22. Epub 2022 Aug 2. J Virol. 2022. PMID: 35916512 Free PMC article.
The continuous antigenic variation of influenza A viruses remains a major hurdle for vaccine selection; however, the molecular determinants and mechanisms of antigenic change remain largely unknown. ...Of note, residues 190 and 230 have synergistic effects on recept …
The continuous antigenic variation of influenza A viruses remains a major hurdle for vaccine selection; however, the molecular determ …
48,518 results
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